Glutathione S-Transferase π Expression in Transitional Cell Carcinoma of Bladder
10.3321/j.issn:1000-467X.2001.01.018
- VernacularTitle:谷胱甘肽S-转移酶-π在膀胱移行细胞癌的表达及其临床意义
- Author:
Hui-Liang ZHOU
1
;
Yi-Qi LUO
;
Sheng ZHANG
;
Lin-Sheng CAO
Author Information
1. Department of Urology
- From:Chinese Journal of Cancer
2001;20(1):72-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective： The current study was designed to investigate the expression of glutathione s-transferase π ( GST-π ) and its clinical significance in human primary transitional cell carcinoma(TCCs) of bladder. Methods： A total of 107 human primary bladder TCCs of the previously untreated patients were analyzed for expression of GST-π and P-glycoprotein (Pgp) by SP immunohistochemistry (IHC). Results： The GST-π positive staining were divided into three groups： single cytoplastic staining, single nuclear staining, both cytoplastic and nuclear staining. GST-π were present in 72.9％ generally, GST-π cytoplastic staining (single cytoplastic, both cytoplastic and nuclear staining) were found in 58.9％ of the samples, 46.7％ of them were positive nuclear staining (single nuclear, both cytoplastic and nuclear staining). GST-π general positive staining and cytoplastic positive staining were significantly correlated with grade, stage and recurrence after post-operative intravesical chemotherapy. Both of them were also strongly related to the expression of Pgp. While GST-π nuclear positive staining was related to stage but not with grade and recurrence. Conclusions： Overexpression of GST-π can be used as a predictive marker of post-operative intravesical chemotherapy in TCCs. Furthermore increased cytoplastic staining is a better predictor of drug resistance while increased nuclear staining might be associated with progression in TCCs.
