Expression of Vascular Endothelial Cell Growth Factor and KDR Receptor in Gastric Adenocarcinoma and its Clinical Significance
10.3321/j.issn:1000-467X.2001.01.015
- VernacularTitle:胃腺癌的血管内皮细胞生长因子和KDR受体的表达及其临床意义
- Author:
Rui-Fang ZHANG
1
;
Yong-Bao CAI
;
Wei-Liang HUANG
;
Yu-Fang ZHU
;
Yan ZENG
;
Dong XIAO
;
Sheng-Tao YUAN
;
Jian DING
Author Information
1. Xuhui District Central Hospital
- From:Chinese Journal of Cancer
2001;20(1):61-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective： The current study was designed to investigate the expression of vascular endothelial cell growth factor (VEGF) and its receptor KDR (VEGFR) in gastric adenocarcinoma and its clinicopathologic significance. Methods： Expression of VEGF/VEGFR in gastric adenocarcinoma was determined by immunohistochemical staining, and the relationship between VEGF/VEGFR expression and the pathological features in 61 cases of gastric adenocarcinoma were analyzed. Results： The positive VEGF/VEGFR expression were detected in 34(55.9％ ) and 24 (39.3％ ) tumor samples respectively. The expressions of VEGF/VEGFR in mucous adenocarcinoma(71.4％ /42.8％ )and in tubular adenocarcinoma(61.9％ /52.4％ ) were obviously higher than those of the other three classes of gastric adenocarcinoma(P< 0.05,P< 0.01). VEGF/VEGFR expression was significantly related to pathological TNM grade(P< 0.05,P< 0.01), and the positive rates of Grade Ⅳ ,Ⅲ ,Ⅱ and Ⅰ were 80.0％ /50.0％ ,68.2％ /45.5％ ,40.0％ /30.0％ and 36.8％ /31.6％ ,respectively. A strong correlation was found between VEGF/VEGFR expression and gastric adenocarcinoma metastasis(P< 0.05,P< 0.01). With regard to prognosis, VEGF positive tumors(66.7％ ) of under one year survival was significantly higher than that of over one year survival(52.2％). Conclusions: VEGF is a promote factor responsible for the induction of angiogenesis in gastric adenocarcinoma. VEGF/VEGFR positive expression may be a useful indicator for estimation of metastasis, pathological staging and prognosis in gastric adenocarcinoma.
