Preliminary investigation and risk analysis of the infection with lymphocytic choriomeningitis virus and hantavirus in 139 cross-border migrant workers
10.3760/cam.j.cn112866-20221214-00254
- VernacularTitle:139名跨境工作人员淋巴脉络丛脑膜炎病毒和汉坦病毒感染调查分析
- Author:
Hao LI
1
;
Meijun GUO
;
Xiaoxia HUANG
;
Shanshan DU
;
Wei WU
;
Aqian LI
;
Qin WANG
;
Chuan LI
;
Tiezhu LIU
;
Tingting TIAN
;
Lina SUN
;
Shiwen WANG
;
Mifang LIANG
;
Dexin LI
;
Jiandong LI
Author Information
1. 中国疾病预防控制中心病毒病预防控制所 卫生部医学病毒和病毒病重点实验室，北京 102206
- Keywords:
Lymphocytic choriomeningitis virus;
Hantavirus;
Cross border;
Rodents
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prevalence of lymphocytic choriomeningitis virus (LCMV) and hantavirus (HV) specific antibodies among cross-border migrant workers for assessment of the risk of rodents-borne virus infection.Methods:From 2019 to 2020, a survey was conducted on cross border migrant workers engaged in outdoor activities, and serum samples were collected, LCMV specific IgG antibody was detected by an indirect ELISA and Western blot based on recombinant nucleoprotein, and indirect immunofluorescence assay (IFA) based on recombinant expressed glycoprotein. HV IgG antibody in serum was detected by a commercial indirect IgG ELISA kit and IFA based on hantavirus infected Vero cells.Results:A total of 139 cross-border workers, aged 25~57, were surveyed; 64% (89/139) had working experience in multiple countries, involving 26 countries, including 14 countries in Asia and 12 countries in Africa; 11.51% (16/139) of serum samples were tested positive for LCMV antibodies, and the positive samples were verified by Western blot and IFA. The antibody detection rate was slightly higher than the published infection rate from other similar studies. And, HV antibodies were detected from one serum sample (0.72%, 1/139) by ELISA and IFA. However, it was still uncertain when and where the viral infections were acquired.Conclusions:Through this serological cross-sectional preliminary analysis, the infection status and existing risks of LCMV and HV viruses among cross border migrant workers were revealed, which suggested the necessity of strengthening the prevention and control of rodents borne diseases in outdoor engineering sites.
