Cyclin A Expression in Non small Cell Lung Carcinoma as Related to Proliferative Activity and Prognosis
10.3321/j.issn:1000-467X.2001.01.009
- VernacularTitle:细胞周期素A的表达与非小细胞肺癌增殖及预后的关系
- Author:
Hui-Ying YU
1
;
Cheng-Guang SHI
;
Ji-Jiang ZHU
;
Zong-Xuan LI
;
Xue-Shan QIU
;
En-Hua WANG
Author Information
1. Chinese Medical University
- From:Chinese Journal of Cancer
2001;20(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective： The current study was designed to investigate the relationship between cyclin A expression in non-small cell lung carcinoma (NSCLC) and the proliferative activity and the prognosis. Methods： Cyclin A expression in 60 non-small cell lung carcinoma specimens was detected by immunohistochemical method. DNA content was measured by flow cytometry. Results： Twenty-nine cases (48.3％ ) showed cyclin A expression. The median S-phase fraction of the cyclin A-positive 14.4± 3.9％ was higher than that of the cyclin A-negative 9.4± 3.5％ . The overall survival was significantly lower in patients with cyclin A expression than in those without cyclin A expression. Conclusion： Cyclin A expression contributed to the high proliferative activity in non-small cell lung carcinoma cells. Cyclin A might be a prognostic marker of non-small cell lung carcinoma.
