Analysis of the epidemic characteristics and disease burden of herpangina in hospitalized children in China from 2016 to 2020
10.3760/cma.j.cn112866-20220714-00159
- VernacularTitle:2016—2020年我国儿童疱疹性咽峡炎住院病例流行特征及疾病负担分析
- Author:
Yiliang FU
1
;
Hui XU
;
Qi LI
;
Guoshuang FENG
;
Xiangpeng CHEN
;
Zhengde XIE
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院 北京市儿科研究所 感染与病毒研究室 儿科重大疾病研究教育部重点实验室 国家呼吸系统疾病临床医学研究中心 儿童呼吸道感染性疾病研究北京重点实验室 中国医学科学院儿童危重感染诊治创新单元，北京 100045
- Keywords:
Herpangina;
Children;
Epidemiology;
Disease burden
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(1):7-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prevalence and burden of herpangina(HA)in Chinese children from 2016 to 2020, which provides basic data reference for the diagnosis, treatment and prevention and control of HA in China.Methods:The homepage information of hospitalized children with HA were collected from 27 children′s hospitals and maternal and child health hospitals in 23 provinces of China from 2016 to 2020 and the epidemiology, severity and disease burden of HA were descriptively and statistically analyzed.Results:A total of 24, 099 hospitalized children with HA were reported from 27 children′s hospitals and maternal and child health hospitals in 2016-2020. In all that the hospitalized children, the male-to-female ratio was 1.46∶1 and 23, 432 children (97.23%) were ≤ 6 years old. HA onset lasted from April to September and its peak was in June or July every year except 2020. The largest number of hospitalized children with HA were found in East China (8, 520/23, 849; 35.72%). During study years, the proportion of hospitalized children with HA among all admissions in 27 investigated hospitals was 0.42% (24, 099/5, 790, 910). In terms of regions, the highest proportion was in Northeast China 0.69% (1, 720/249, 244). A total of 1, 510 (6.27%) children were severe cases and the male-to-female ratio was about 1.35∶1; 1, 326 (87.81%) children were ≤ 3 years old and the highest proportion of severe cases was in 28 days to ≤ 1 years old children (7.47%, 784/10, 494). The median of expenses for hospitalized children with HA was 3, 570.41 RMB (IQR 2, 698.03-4, 747.30), and the median hospital stay was 5 days (IQR 4-6).Conclusions:HA onset in China was predominantly in summer and at the age of ≤ 6 years. Meanwhile, owing to a large number of hospitalized children with HA and the high expenditures they generated, HA caused a considerable disease burden.
