Application of next-generation sequencing in the detection of emerging outbreak of virus infection
10.3760/cma.j.cn112866-20220627-00144
- VernacularTitle:二代测序在新发突发病毒检测中的应用
- Author:
Yu BAI
1
;
Yang LI
;
Wenli LIU
;
Lei LIU
;
Yigang TONG
Author Information
1. 佳木斯大学基础医学院，佳木斯 154007
- Keywords:
Next-generation sequencing;
Infectious diseases;
Virus;
Pathogen
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(6):739-747
- CountryChina
- Language:Chinese
-
Abstract:
The spread of current emerging outbreaks of virus infections already poses a serious threat to public health and has the potential to trigger devastating epidemics worldwide. Therefore, it is especially significant to strengthen the detection of viral diseases. Next-generation sequencing (NGS) not only enables the accurate identification of pathogens but can also be combined with bioinformatics to monitor emergent infectious diseases based on the sequencing of pathogen genomes, further enhancing the level of clinical diagnosis and microbiological recognition. This review discusses the application of NGS to detect the pathogens of emerging outbreaks of viral diseases, and to further investigate their variation and evolution characteristics, pathogenic mechanisms and transmission patterns, and apply NGS in clinical practice to address the diagnosis of difficult infectious diseases so that more effective strategies can be developed to prevent emerging outbreaks.
