Advances in technology and application of serological tests for HIV infection
10.3760/cma.j.cn112866-20221017-00213
- VernacularTitle:HIV感染的血清学检测技术与应用研究进展
- Author:
Xiaoxu HAN
1
;
Xin ZHANG
;
Xiaolei XU
;
Jin SUN
;
Hongxia YAN
;
Xiuwen WANG
;
Tong ZHANG
;
Cong JIN
;
Bin SU
Author Information
1. 首都医科大学附属北京佑安医院感染性疾病临床研究中心 艾滋病研究北京市重点实验室，北京 100069
- Keywords:
HIV;
Infection;
Serological test;
Antibody;
p24 antigen;
Biosensor
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(6):732-738
- CountryChina
- Language:Chinese
-
Abstract:
HIV infection is a serious challenge to global public health. Timely and accurate early diagnosis and early initiation of antiretroviral therapy can effectively resist the spread of the virus, and improve the immune function of HIV-infected patients, thereby improve patients′ outcomes and reduce patients′ hospitalization and mortality. Efficient and sensitive testing is a prerequisite for early diagnosis of HIV infection and is also a focus in the prevention and control of HIV epidemics. Serologic testing has been the most widely used HIV detection technology till now. However, it has been difficult for the traditional antibody detection technology to detect HIV acute infection in a timely and accurate manner and therefore restricted the early diagnosis of HIV infection. In recent years, a variety of new detection technologies, such as HIV antigen/antibody combined detection and biosensors, with their high sensitivity, have significantly shortened the window period for the diagnosis of HIV infection, bringing new hope for early diagnosis of HIV. This paper reviews the principle, scope of application, and application prospect of serological detection technology for HIV infection and provides a reference for the development of new HIV testing strategies.
