Enhanced expression of matrix metalloproteinase 7 in pancreatic carcinoma
10.3321/j.issn:1000-467X.2000.06.004
- VernacularTitle:胰腺癌组织中基质金属蛋白酶-7(MMP7)的表达
- Author:
Yu-Xin HU
1
;
Ping LI
;
Bao-Shu LIU
;
Hiroyuki WATANABE
;
Norio SAWABU
Author Information
1. Changhai Hospital
- Keywords:
Pancreatic neoplasms;
Matrix metalloproteinase 7(MMP7);
Immunohistochemistry
- From:Chinese Journal of Cancer
2000;19(6):521-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Matrix metalloproteinases7(MMP7)is reported to be involved in the invasion and metastasis of some human tumors.In this study ,we investigated the role of MMP7 in human panereatic careinoma(PC)progression.Materials and Methods:A total of 51 cases of PC,including 22 early lesions(clinical stage Ⅰ and Ⅱ)and 29 of advanced ones(clinical stageⅢ and Ⅳ),were tested for MMP7 expression using immunostaining assay.Results:Increased MMP7 immunoreactivity was present in 35(68.6%)cases of PC,and frequently distributed in the invasive front of the tumors.More cases expressed positive MMP7 in advanced group(23/29,79.3%)than in early group(12/22,54.5%;P<0.05).Conclusion:The increased expression of MMP7 was related to PC progression and might be considered to be useful as a marker for biological aggressiveness of this malignancy.
