Real-world study on predictors of postpartum hepatitis in pregnant women with chronic HBV infection
10.3760/cma.j.cn112866-20211107-00195
- VernacularTitle:慢性HBV感染孕妇产后肝炎发作预测因素真实世界研究
- Author:
Zhan ZENG
1
;
Mingfang ZHOU
;
Xiaoyue BI
;
Yanjie LIN
;
Liu YANG
;
Wen DENG
;
Tingting JIANG
;
Leiping HU
;
Mengjiao XU
;
Lu ZHANG
;
Minghui LI
;
Yao XIE
Author Information
1. 北京大学地坛医院教学医院，北京 100015
- Keywords:
Chronic HBV infection;
Pregnancy;
Postpartum hepatitis;
Predictors
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(6):696-700
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the predictors of postpartum hepatitis in pregnant women with chronic HBV infection.Methods:In this retrospective study, liver function and hepatitis B virology tests of pregnant women with chronic HBV infection at delivery and within 48 weeks were collected from the clinical medical system after the enrollment of eligible patients. Statistical analysis was performed on the obtained data.Results:A total of 533 pregnant women meeting the criteria were enrolled, and the average age of all patients was 29.5±3.7. A total of 408 pregnant women took antiviral drugs during pregnancy for prevention of mother-to-child transmission; 231 patients developed hepatitis within 1 year after delivery. There were significant differences in alanine transaminase (ALT), aspartate transaminase (AST), HBV DNA during delivery, hepatitis B e antigen (HBeAg) during delivery and baseline HBeAg between patients with and without hepatitis. Multivariate binary logistic regression analysis showed that HBeAg ( OR=0.19, 0.074-0.473; P<0.001), ALT ( OR=1.05, 1.021-1.071; P<0.001), albumin ( OR=0.91, 0.833-0.995; P=0.038), platelet ( OR=0.995, 0.992-0.999; P=0.01), neutrophils ( OR=0.98, 0.973-0.995; P=0.004) had significant difference. Conclusions:Baseline HBeAg and ALT are powerful predictors of postpartum hepatitis in pregnant women with chronic HBV infection.
