Clinical significance of expressions of bcl-2,p170,and CD34 in leukemia
10.3321/j.issn:1000-467X.2000.02.014
- VernacularTitle:白血病bcl-2,p170,CD34表达的临床意义及其相关性
- Author:
Bao-Hua DUAN
1
;
Shao-Jun LIU
;
Yu-Ren XI
Author Information
1. 河南医科大学附属第二医院
- Keywords:
Leukemia;
bcl－2;
p170;
CD34;
MDR
- From:Chinese Journal of Cancer
2000;19(2):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study and assess the clinical significance of the expressions of bcl－2,p170,and CD34 in leukemia and their correlations. Methods:ABC immunocytochemistry was used in detection of the expressions of bcl－2,p170,and CD34 in leukemic cells from 77 cases of acute leukemia(AL)and 23 cases of chronic myeloid leukemia (CML) patients. Results:The expression rates of bcl－2,p170,and CD34 in relapsed or refractory acute leukemia were significantly higher than those in the untreated acute leukemia. The complete remission rates were significantly lower in the patients with overexpression than in those with low－/non－expression of one of the detected markers,bcl－2,p170 and CD34. The expression of CD34 in CML accelerative or excess blast phase was higher than that in chronic phase. It was found that the positive coincidence rates were 90.9％ for overexpression of bcl－2,which was a little higher than that of p170 or CD34. It was showed that there was slightly positive correlation between the expression rates of bcl－2 and p170 (r=0.386,P<0.001). Conclusion:There is more sensitive predictive value of bcl－2 among these three markers. The combined detection of bcl－2,p170 and CD34 may improve the predictive value of each. It was also suggested that CD34 could be a poor indicator in the course of CML. There may be some correlation among the different MDR mechanisms.
