Clinical characteristics of diarrhea among children infected with rotavirus in Beijing, 2011 to 2018
10.3760/cma.j.cn112866-20220514-00116
- VernacularTitle:2011—2018年北京市轮状病毒感染所致腹泻儿童的临床特征分析
- Author:
Yi TIAN
1
;
Hanqiu YAN
;
Weihong LI
;
Baiwei LIU
;
Xiaona WU
;
Lei JIA
;
Quanyi WANG
;
Zhiyong GAO
Author Information
1. 北京市疾病预防控制中心传染病地方病控制所，北京 100013
- Keywords:
Children;
Rotavirus;
Diarrhea;
Clinical characteristics
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(6):685-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To provide evidence for clinical diagnosis, prevention and control of group A rotavirus (RVA) diarrhea, the clinical characteristics of RVA diarrhea in children in Beijing from 2011 to 2018 were analyzed.Methods:From January 2011 to December 2018, 4 819 stool samples from children under 5 years old with diarrhea were collected monthly from 3 hospitals in Beijing. General information, clinical characteristics and other information of children were collected. RVA was detected by enzyme-linked immunosorbent assay (ELISA), genotype was identified by multiple semi-nested RT-PCR. The Vesikari clinical severity score was used to define the severity of diarrhea in children. Dichotomous unconditional logistic regression was used to analyze clinical symptoms and other differences between RVA positive and negative cases. Chi-square and Fisher direct probability tests were used to compare the composition among different groups.Results:A total of 4 819 fecal samples were collected, 953 were positive for RVA, the positive detection rate was 19.78%. The positive rate of RVA was high in the younger age group, and the incidence was high in winter and spring. RVA-positive children had more risk on diarrhea ≥5 times a day, vomiting symptoms, fever, mild dehydration, and Vesikari score ≥11. The positive rate of RVA in watery stool samples (26.13%, 214/819) and infectious diarrhea cases (42.20%, 265/628) was the highest respectively. There were no significant differences in clinical symptoms, clinical diagnoses and fecal traits among children with different RVA genotypes.Conclusions:The clinical symptoms of RVA diarrhea were severe in children. RVA genotype did not affect the clinical symptoms. Stool traits (watery stools) and Vesikari score can assist physicians in diagnosing RVA diarrhea.
