Detection of plasma cofilin protein for diagnosis of lung cancer
- VernacularTitle:血浆cofilin蛋白检测在肺癌诊断中的价值
- Author:
Yuju ZHENG
1
;
Ye FANG
;
Shaojin LI
;
Bangxi ZHENG
Author Information
1. 汕头潮南民生医院暨汕头大学医学院第一附属医院 心胸外科
- Keywords:
cofilin protein;
lung cancer;
staging
- From:
Journal of Southern Medical University
2013;(10):1551-1553
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect serum content of cofilin protein in patients with lung cancer and investigate its clinical value. Methods The serum content of cofilin protein was detected in 30 cases of lung cancer and 30 healthy control subjects using enzyme-linked immunosorbent assay. Results The mean serum content of cofilin protein was 0.485 ± 0.465 ng/ml in patients with lung cancer and 0.203 ± 0.102 ng/ml in the control subjects, showing a significant difference between them (P<0.05). The content of cofilin protein in patients with stage III and IV lung cancer 0.744±0.584 ng/ml, significantly higher than that in stage II patients (0.257±0.126 ng/ml). Conclusion Serum cofilin protein is elevated in patients with lung cancer, especially in cases in advanced stages, suggesting its relation with lung cancer staging.
