Investigation of specific IgG antibody in healthy population after vaccination with COVID-19 vaccine in Xizang Autonomous Region, China
10.3760/cma.j.cn112866-20220628-00146
- VernacularTitle:西藏自治区健康人群接种新型冠状病毒肺炎疫苗后特异性IgG抗体调查
- Author:
Mei HONG
1
;
Qin WANG
;
Deji SUOLANG
;
Guolong DAI
;
Quzha DANGZENG
;
Wentao ZHAO
;
Zhuoga CIDAN
;
Yang SUO
;
Zhuoga BAIMA
;
Yang LUO
;
Yuhua QI
;
Xiuwen MA
;
Ma ZHUO
;
Duoji CIREN
;
Changjiu YE
;
Yangzong CIREN
;
Sezhen DEJI
;
Zhen NI
Author Information
1. 西藏自治区疾病预防控制中心，拉萨 850000
- Keywords:
2019 novel coronavirus;
Vaccine;
Antibody;
Booster immunization
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(6):644-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the positive rate of 2019 novel coronavirus (2019-nCoV) specific IgG antibody induced by Coronavirus Disease 2019 (COVID-19) inactivated vaccine in healthy population in Xizang Autonomous Region, and evaluate the immune effect of the vaccine.Methods:Serum samples were collected from COIVD-19 vaccine immunized health population without history of 2019-nCoV infection from six prefecture-level cities in Xizang Autonomous Region. The IgG antibody against 2019-nCoV were tested by chemiluminescence method. Then, the positive rate of IgG antibody was analyzed for different immunization histories and age groups.Results:A total of 22 255 participants were enrolled in this survey. After full-access (two doses of vaccine) and booster immunization, the overall positive rate of specific IgG antibody against 2019-nCoV was 96.38%. The positive rate of IgG antibody in the booster immunized population was 97.12%, which was much higher than the 88.38% in the full-access immunization population, the difference is statistically significant ( χ2=381.11, P<0.001). There was a significant differences in the positive rates of specific IgG antibodies in different age groups ( χ2=138.28, P<0.001). Especially in the younger age groups, including less than 10 years old and the 11-20 years age group, the positive rate of specific IgG antibody were 93.44% and 89.03% respectively, which were lower than those in other age groups. Except for Naqu city and the age group ≤ 10 years old, the differences in antibody positivity rates were statistically significant between different age groups in the same region and between the different regions in the same age group for the two populations with different immunization histories ( P<0.05). Conclusions:The COVID-19 inactivated vaccine showed a good immune effect in the healthy population in Xizang Autonomous Region, and the booster immunization helps to increase the positive rate of specific IgG antibody in healthy population.
