Association of T393C single nucleotide polymorphism of GNAS1 gene with non-valvular atrial fibrillation
- VernacularTitle:GNAS1基因T393C单核苷酸多态性与非瓣膜性房颤的相关性
- Author:
Hong LI
1
;
Zhaoting HU
;
Zhenni TAN
;
Qingzhen HOU
;
Jian PENG
Author Information
1. 南方医科大学1南方医院心内科
- Keywords:
non-valvular atrial fibrillation;
GNAS1 gene;
single nucleotide polymorphisms;
heart rate variability
- From:
Journal of Southern Medical University
2013;(10):1508-1511
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association between T393C single nucleotide polymorphism (SNP) of GNAS1 gene and non-valvular atrial fibrillation (AF) in Chinese Han patients. Methods Ninety patients with non-valvular AF and 90 healthy subjects were examined for T393C SNP of GNAS1 gene using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The allele genotypes and the distribution of allele frequencies were analyzed and compared between the two groups. The relationship between allele frequency distribution characteristics and the heart rate variability (HRV) were also studied for analysis of the association between T393C SNP of GNAS1 gene and the autonomic nervous activation in non-valvular AF. Results The two groups showed a significant difference in the frequencies of genotypes of T393C SNP of GNAS1 gene and allele frequencies (P<0.01). CC genotype and T393C allele frequency were significantly increased in the case group. pNN50, LF, or LF/HF showed no significant difference between different genotypes (P<0.05). Conclusion The T393C SNP of GNAS1 gene is closely associated with non-valvular AF in Chinese Han patients.
