Progress in studies on the role of miRNA in enterovirus-A71—host cell interaction

VernacularTitle:miRNA在肠道病毒A71型与宿主细胞互作中的研究进展
Author: Houguang LIU ¹ ; Qing REN ; Pingping SUN ; Guangcheng XIE
Author Information

1. 厦门市第三医院，厦门　361100
Keywords: miRNA; Enterovirus-A71; Pathogen; Host; Interaction
From: Chinese Journal of Experimental and Clinical Virology 2022;36(5):615-619
CountryChina
Language:Chinese
Abstract: Hand, foot, and mouth disease (HFMD) caused by enterovirus-A71 (EV-A71) has posed heavy disease and economic burdens to young children under 5 years of age and families. Elucidating the pathogenesis of EV-A71 will provide better evidence for prevention and control for EV-A71 infection. miRNAs are a class of non-coding RNA that regulate many biological processes of host cells through manipulating mRNA translation to control the protein levels by direct binding to mRNA, meanwhile, participating the virus-host cell interaction. Here, we mainly review the current knowledge on the biogenesis of miRNA, alterations of miRNA profiles induced by EV-A71, regulation of EV-A71 replication, anti-EV-A71 innate immunity and apoptosis by miRNA direct binding EV-A71 genome or host genes. All these will facilitate understanding the role of miRNA in EV-A71-host cell interaction and pathogenesis of disease caused by EV-A71.