Epidemiological characteristics of hand, foot and mouth disease cases caused by coxsackievirus group A type 6 in Xi’an city, 2016-2020
10.3760/cma.j.cn112866-20220210-00027
- VernacularTitle:2016—2020年西安市手足口病中柯萨奇病毒A组6型感染的流行特征
- Author:
Zerun XUE
1
;
Rui WU
;
Hailong CHEN
;
Quanli DU
;
Yuewen HAN
;
Yujie YANG
;
Yangni DENG
;
Leile ZHANG
;
Peng ZHANG
;
Chaofeng MA
Author Information
1. 西安市疾病预防控制中心病毒科，西安 710054
- Keywords:
Coxsackievirus;
Hand, foot and mouth disease;
Epidemiological characteristics
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(5):564-568
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To characterize the epidemiology of hand, foot and mouth disease (HFMD) cases caused by coxsackievirus group A type 6 (CV-A6) in Xi’an from 2016 to 2020 and provide evidence for the prevention and control of HFMD.Methods:The enterovirus (EV) types were identified using real-time RT-PCR. The data of HFMD cases were collected from the National Notifiable Infectious Diseases Reporting System of China Center for Disease Control and Prevention. Descriptive epidemiological method were used to analyze the distributions and the data were statistically analyzed with Excel 2007 and SPSS 18.0.Results:In the 4 034 HFMD cases, 17.85% had enterovirus group A type 71 (EV-A71) infections, 23.92% had coxsackievirus group A type 16 (CV-A16) infections, and 47.79% had other EV infections. 2 571 HFMD cases were randomly selected, including 1 268 other EV positive cases. The detection rate of CV-A6 in HFMD cases was 34.73% (893/2 571), and the constituent ratio of CV-A6 in other EV positive cases was 70.43% (893/1 268). The cases mainly occurred in children aged≤5 years (95.18%), more boys were affected than girls (1.47∶1). HFMD caused by CV-A6 was concentrated in April to June. Compared with EV-A71 and CV-A16, the clinical classification had significant difference in CV-A6 group ( χ2=139.55, P<0.001), but the ratio of sex and age-group had no significant difference ( F=2.74, P=0.065; χ2=2.43, P=0.297). Conclusions:The predominant pathogen of HFMD in Xi’an from 2016 to 2020 were other EV, among which CV-A6 accounted for the highest proportion in other EV positive cases. It is necessary to strengthen the prevention and control of HFMD caused by CV-A6 and carry out the surveillance for various pathogens of HFMD.
