Role of group 2 innate lymphoid cells in viral infectious diseases

VernacularTitle:2型固有淋巴细胞在病毒感染性疾病中的作用
Author: Huimin DING ¹ ; Zhenyu LU ; Yuan LI ; Ying WANG ; Peifeng JIA ; Xiaoyu GAO ; Chunmei YUN
Author Information

1. 内蒙古医科大学，呼和浩特　010059
Keywords: Group 2 innate lymphoid cells; Virus infection; Immune; Inflammatory
From: Chinese Journal of Experimental and Clinical Virology 2022;36(4):481-487
CountryChina
Language:Chinese
Abstract: Group 2 innate lymphoid cells (ILC2s) are novel innate immune cells. Similar to T cells, ILC2s can secrete Th2 cytokines and initiate and maintain type 2 immune responses, which are also named as cross-border immune cells between innate immunity and adaptive immunity. In recent years, infectious diseases caused by pathogenic viruses have become a global healthcare challenge with the outbreaks of Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS) and novel coronavirus disease 2019 (COVID-19). As a member of the innate lymphocyte family, ILC2s are involved in the development of group 2 inflammatory diseases and can activate immune activity, playing an essential role in the repair of tissue damage and in the body’s defense, which also can participate in the immune response and play an important role in viral immunity when a virus attacks on the body. This study reviews the defensive role of ILC2s in viral infections, providing a theoretical basis for elaborating the role of ILC2s in viral infectious diseases.