Relationship between heroin spongiform leucoencephalopathy and respiratory chain complex I deficiency
10.3969/j.issn.1673-4254.2013.09.22
- VernacularTitle:线粒体呼吸链复合物Ⅰ缺陷与海洛因海绵状白质脑病的关系
- Author:
Liang ZHOU
1
;
Minshi LIN
;
Jia YIN
Author Information
1. 南方医科大学南方医院神经内科
- Keywords:
heroin;
leucoencephalopathy;
mitochondrial respiratory chain;
complex I deficiency
- From:
Journal of Southern Medical University
2013;(9):1357-1361
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between heroin spongiform leucoencephalopathy and respiratory chain complex I deficiency. Methods The activity of respiratory chain complex I in peripheral white blood cell mitochondria was compared between 36 cases of heroin spongiform leucoencephalopathy and 36 healthy subjects using enzyme-linked immunosorbent assay (ELISA). Results The activity of respiratory chain complex I was 5.6 ± 2.4 U/ml in patients with heroin spongiform leucoencephalopathy, signficiantly higher than that in the normal subjects (4.2 ± 2.1 U/ml, t=2.634, P<0.05). Conclusion In patients with heroin spongiform leucoencephalopathy, mitochondrial dysfunction results in energy metabolism disorder to cause extensive demyelination of the cerebral white matter. Respiratory chain complex I deficiency of the mitochondria plays a significant role in the pathogenesis of heroin spongiform leucoencephalopathy.
