Prognostic value and risk factors of anemia grade in patients with hepatitis B virus-related acute-on-chronic liver failure
10.3760/cma.j.cn112866-20220323-00066
- VernacularTitle:HBV相关慢加急性肝衰竭贫血分级和危险因素及其对预后的影响
- Author:
Wanshu LIU
1
;
Fangjiao SONG
;
Qinghui ZHAI
;
Xinyang LIAO
;
Wenjun LIU
;
Dongze LI
;
Shaojie XIN
;
Bing ZHU
;
Shaoli YOU
Author Information
1. 中国人民解放军总医院第五医学中心肝病医学部，北京 100039
- Keywords:
Acute-on-chronic liver failure;
Anemia;
Risk factors;
Prognosis
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(4):436-440
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of anemia and prognostic value of different grades of anemia in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Methods:Anemia grades of 1 163 patients with HBV-ACLF were analyzed and the effect of different grades on prognosis were evaluated. The risk factors related to anemia were evaluated by Spearman rank correlation analysis and logistic regression analysis.Results:Among 1 163 patients, 942 (80.99%) patients had anemia. The incidence of grade 2 and 3 (moderate and severe) anemia in type B and C HBV-ACLF patients was significantly increased ( χ2=72.908, P<0.001). The incidence of macrocytic anemia among type A, B and C HBV-ACLF ranged from 13.0% to 43.98% and 58.33%, respectively( χ2=46.823, P <0.001). The 1-year cumulative survival rate of patients with grade 2 and 3 anemia decreased significantly( χ2=50.179, P<0.001); Spearman rank correlation analysis showed that the correlation coefficient between ABC type and anemia grade was 0.319, P<0.001. Logistic regression analysis showed that gastrointestinal bleeding, acute kidney injury (AKI) and ABC types were independently associated with grade 2 and 3 anemia in patients with HBV-ACLF. Conclusions:Anemia grade is closely related to the prognosis in patients with HBV-ACLF. Gastrointestinal bleeding, AKI and ABC types are independent risk factors for grade 2 and 3 anemia in patients with HBV-ACLF.
