Evaluation and study on the effect of nucleic acid testing in blood screening on the residual risk of transfusion transmitted HBV infection
10.3760/cma.j.cn112866-20220309-00054
- VernacularTitle:血站核酸筛查模式对输血传播HBV残余风险影响的评估研究
- Author:
Min HUANG
1
;
Lin BAI
;
Changchun LU
;
Shanshan ZHU
;
Yujun LI
;
Zhian ZHANG
;
Haili MA
;
Rong YOU
;
Yanli QIN
;
Bing JU
;
Wei HAN
;
Fang WANG
;
Xue CHEN
;
Xiaohua YUAN
;
Xingli REN
;
Lei ZHAO
;
Linghao ZHANG
;
Xing YI
;
Yan QIU
Author Information
1. 南京红十字血液中心检验科，南京 210003
- Keywords:
Hepatitis B virus;
Residual risk of blood transfusion;
NAT yield/WP ratio model;
Nucleic acid test;
Blood screening strategy
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(4):429-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To preliminarily estimate and study the effect of nucleic acid testing in blood screening on the residual risk (RR) of transfusion transmitted HBV infection (TTI HBV).Methods:Using the NAT yield/WP ratio model and adopting the relevant data of information management system of practice comparison working party in the Mainland of China, this paper analyzed the trend of the RR of TTI HBV among 18 blood centers from 2015 to 2019 in China, and compared the impact of two kinds of blood screening strategies which were ELISA+ ID-NAT/MP-NAT (individual-donation nucleic acid testing or mini-pool nucleic acid testing) and ELISA + MP-NAT on RR in 2019.Results:The overall trends of the 5-year RR of HBV among 18 blood centers showed by trend chi square test were NAT single positive rate trend χ2= 39.42( P<0.01) and residual risk trend χ2= 279.792( P<0.01); The influence on RR from the differences of ELISA+ ID-NAT/MP-NAT and ELISA+ MP-NAT was statistically significant, and chi square test showed that χ2= 7.4( P<0.01). Conclusions:Since the implementation of nucleic acid testing in the blood screening in China from 2015, the residual risk of transfusion transmitted HBV infection has decreased year by year. The observed two blood screening strategies which dominated in China may lead to discrepancy in the residual risk of TTI.
