Dual role of autophagy in viral infection
10.3760/cma.j.cn112866-20220116-00007
- VernacularTitle:自噬在病毒感染中的双重作用
- Author:
Yazhi SU
1
;
Tao WANG
;
Zhiyun WANG
Author Information
1. 天津大学生命科学学院，天津 300000
- Keywords:
Autophagy;
Innate immunity;
Adaptive immunity;
Virus replication
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(3):366-370
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a conserved, inherent cellular mechanism involving various proteins, which transports cytoplasmic material to the lysosome for degradation. It maintains cell homeostasis by ensuring the renewal of abnormal/senescent organelles and the circulation of nutrients. Autophagy is also an important intracellular defense mechanism. It blocks virus invasion by targeting viral particles or viral components for degradation. It can also promote the interaction of viral components with receptors in the innate immune pathway to stimulate the production of interferon, and even can utilize the autophagosome membrane or autophagosome for self-replication. In order to cope with such pressure, viruses have evolved various complex strategies to antagonize the antiviral effects of the autophagy. This review aims to summarize the role of autophagy in antiviral immunity and the specific mechanism of virus regulating autophagy. It also briefly introduces the research progress in autophagy-related diseases and therapeutic drugs.
