Pathogen spectrum of febrile respiratory syndrome among hospitalized children in Shanghai from 2019 to 2020
10.3760/cma.j.cn112866-20220209-00025
- VernacularTitle:2019—2020年上海市住院儿童病例发热呼吸道症候群病原谱研究
- Author:
Chun WANG
1
;
Xue ZHAO
;
Zheng TENG
;
Huihong QIN
;
Haoxiang GU
;
Hong ZHANG
;
Xi ZHANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院检验科 200040
- Keywords:
Respiratory tract infection;
Respiratory syncytial virus;
Mycoplasma pneumoniae;
Mixed infection
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(3):270-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the pathogenic spectrum and clinical characteristics of respiratory syndrome among hospitalized children in Shanghai, to provide reference for disease prevention and clinical diagnosis.Methods:Twenty-two pathogens were detected in 634 lower respiratory tract aspirates by using fluorescence quantitative PCR combined with the determination method of dissolution curve, and chi-square test was used for statistical analysis of different detection rates.Results:Among the 634 inpatient specimens, 555 were positive for pathogen nucleic acid, with a total positive rate of 87.54%. The detected pathogens were mainly Mycoplasma pneumoniae (MP), adenovirus (ADV), respiratory syncytial virus (RSV), influenza A virus (FluA) and Boca virus (BoV), and the ratio of multiple pathogen infection was greater than single pathogen infection, the pathogen type of multiple infection was ADV, RSV, FluA or BoV co-infection with MP; in the age distribution, FluA has a higher detection rate in the " <2 year old" and " 2-5 years old" age groups, and RSV had a significantly higher detection rate in the " <2 year old" age group compared with the other two age groups, the detection rate of coronavirus (CoV) in " 2-5 years old" and " >5 years old" is higher than that in " <2 year old" age group; combined with the analysis of clinical symptoms, RSV was found in non-febrile patients. The detection rate of RSV and PIV in cough patients was higher than that in non-cough patients, and the detection rate of RSV in wheezing patients was higher than that in non-wheezing patients. H3N2 in RSV and FluA had a high probability of causing pneumonia; FLuA, FluB and RSV had obvious epidemic peaks in winter and spring.Conclusions:We should strengthen the continuous monitoring of respiratory pathogens such as MP, ADV, RSV, FluA and BoV for the purpose of better understanding the changes in their epidemiological characteristics and pathogenicity, and provide the scientific data for the prevention and control of respiratory diseases in children.
