Distribution of viral load before treatment in HIV cases in Dehong prefecture, Yunnan province
10.3760/cma.j.cn112866-20220321-00062
- VernacularTitle:云南省德宏州新报告HIV感染者治疗前病毒载量分布研究
- Author:
Xin ZHANG
1
;
Jibao WANG
;
Yikui WANG
;
Xing DUAN
;
Jin YANG
;
Tao YANG
;
Shijiang YANG
;
Cong JIN
;
Runhua YE
;
Yuecheng YANG
Author Information
1. 中国疾病预防控制中心性病艾滋病预防控制中心，北京 102206
- Keywords:
HIV;
Baseline viral load;
Antiretroviral therapy
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(3):258-262
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the baseline HIV viral load and demographic characteristics of newly diagnosed HIV cases from 2015 to 2017 in Dehong prefecture and provide a scientific basis for improving HIV prevention and treatment.Methods:All newly reported HIV-infected cases from 2015 to 2017 in Dehong prefecture were included in this study. Viral load, CD 4+ T cell counts and the demographic characteristics were collected and retrospectively analyzed. Results:From 2015 to 2017, a total of 1 157 newly diagnosed HIV cases were reported in Dehong prefecture, of which 1 057 cases were tested for viral load; 64.9% were males, 59.5% aged between 25 and 49, 51.9% were married, 48.2% were Han ethnicity, 48.2% had middle school (or beyond) training and 85% were heterosexual. The median pre-treatment viral load of newly diagnosed HIV-infected individuals was 8 200 (IQR: 1 900-44 000) copies/ml. The proportion of cases with viral load between 10 3-10 5copies/ml was the highest, accounted for 65.7% (694/1 057). There were 5.2% (55/1 057) whose viral load was below the detecting limit and 24 had CD 4+ T cell counts over 500 cells/μl. Conclusions:Baseline viral load levels before treatment vary among HIV-infected individuals. In view of the impact of viral load at baseline on the effectiveness of diagnosis and treatment, it is necessary to perform viral load testing before treatment, and the result can assist in the formulation of a more personalized and effective treatment regimen.
