The first viral load suppression and its influencing factors for HIV/AIDS on ART in Shandong province
10.3760/cma.j.cn112866-20210423-00066
- VernacularTitle:山东省HIV/AIDS抗病毒治疗后首次病毒载量抑制情况及影响因素分析
- Author:
Na ZHANG
1
;
Lianzheng HAO
;
Guoyong WANG
;
Xiaoyan ZHU
;
Xingguang YANG
;
Pengxiang HUANG
;
Ling LI
;
Huifeng SUN
;
Dianmin KANG
;
Tao HUANG
Author Information
1. 山东省疾病预防控制中心，济南 250014
- Keywords:
HIV/AIDS;
Antiretroviral treatment;
Viral load;
Influencing factor
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(2):160-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the status of first viral load (VL) suppression for newly diagnosed HIV/AIDS on antiretroviral therapy (ART) from 2014 to 2016 in Shandong province, to provide theoretical evidence for improvement of ART effectiveness.Methods:Based on a retrospective cohort study, logistic regression model was used to identify influencing factors about VL suppression.Results:There were 4 833 newly diagnosed HIV/AIDS cases who received ART from 2014 to 2016 in Shandong province, and 3 449 cases achieved VL suppression at the first VL testing. The rate of first VL suppression was 71.36%. The possibilities of first VL suppression among patients on ART with education at junior high school, junior college and above were higher than those with education at primary school and below, with OR values at 1.75 and 2.00, separately. The possibilities of first VL suppression for patients treated at medical institutions was higher than those by CDC, with OR value 1.29. The possibilities of first VL suppression among patients whose CD4 count level at 201-350, 351-500 and ≥501 cells/μl were higher than that of the patients whose CD4 count level at ≤200 cells/μl, with OR values at 2.36, 2.11 and 2.66, respectively. The possibilities of first VL suppression among patients who missed doses was lower than those who did not miss doses, with OR value at 0.55. All the Pvalues for the above comparisons was <0.05. Conclusions:The suppression of viral load for HIV/AIDS on ART was influenced by culture level, CD4 count level at the entry of ART, treatment institutions and adherence to the therapy. Earlier diagnosis, treatment services provided by medical institutions and improvement of drug adherence can enhance ART effectiveness.
