Relationship Between Programmed Death-ligand 1 and Clinicopathological Characteristics in Non-small Cell Lung Cancer Patients
- Author:
Chen YAN-YAN
1
;
Wang LIU-BO
;
Zhu HUI-LI
;
Li XIANG-YANG
;
Zhu YAN-PING
;
Yin YU-LEI
;
Li FAN-ZHEN
;
Wang ZI-LI
;
Qu JIE-MING
Author Information
1. Department of Respiratory Medicine
- Keywords:
non-small cell lung cancer;
programmed death-ligand 1;
tumor associated macrophage
- From:
Chinese Medical Sciences Journal
2013;(3):147-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the correlation between programmed death-ligand 1 (PD-L1) expression in primary lung cancer cells, tumor associated macrophages (TAM) and patients’ clinicopathological charac-teristics.
Methods From 2008 to 2010, 208 non-small cell lung cancer patients who underwent surgery or CT-guided biopsy were recruited from Huadong Hospital, Fudan University. Immunohistochemistry staining was performed to evaluate the PD-L1 expression in both primary lung cancer cells and CD68 positive TAM. The relationship between PD-L1 expression and the clinical pathology was evaluated using χ2 test. Spearman’s rank correlations were used to determine the correlation between PD-L1 expression in tumor cells and macrophages.
Results Positive PD-L1 expression in primary cancer cells was found in 136 (65.3%) patients, which were negatively correlated with lymph node metastasis (P=0.009) and smoking history (P=0.036). Besides, TAM with PD-L1 expression (found in 116 patients) was positively associated with smoking history (P=0.034), well-differentiation (P=0.029) and negative lymph node metastasis (P=0.0096). A correlation between PD-L1 expression in primary tumor cells and non-small cell lung cancer associated macrophages was found (r=0.228, P=0.021).
Conclusion PD-L1, secreted from TAM, might induce cancer cells apoptosis, and decrease lymph node metastasis.
