Detection of 2019-nCoV nucleic acid at different time of courses in confirmed COVID-19 cases
10.3760/cma.j.cn112866-20201015-00263
- VernacularTitle:新型冠状病毒肺炎确诊病例不同病程的新型冠状病毒核酸检测分析
- Author:
Zerun XUE
1
;
Haifei YOU
;
Rui WU
;
Yang LUAN
;
Hailong CHEN
;
Quanli DU
;
Yuewen HAN
;
Yujie YANG
;
Yangni DENG
;
Yinjuan HUANG
;
Hao LI
;
Kaixin LI
;
Leile ZHANG
;
Peng ZHANG
;
Chaofeng MA
Author Information
1. 西安市疾病预防控制中心 710054
- Keywords:
COVID-19;
2019-nCoV;
Confirmed cases;
Nucleic acid detection
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(6):728-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the positive rates of 2019-nCoV nucleic acid at different time of courses of COVID-19.Methods:Patients with confirmed COVID-19 were enrolled in this study. Nasal and throat swabs were collected from different courses of disease. Real-time RT-PCR was used to detect 2019-nCoV nucleic acid.Results:From January 23 to February 20, 2020, a total of 120 confirmed cases of COVID-19 were reported in Xi’an, and 85 cases(70.83%) were positive in first detection. The COVID-19 cases included consistently nucleic acid positive and intermittently nucleic acid positive patients. 2019-nCoV nucleic acid could be detected in incubation period, and the longest observed duration of nucleic acid positive in this study was 26 days. The positive rate of 2019-nCoV nucleic acid was up to 84.21% on the 6th day, and the positive rate decreased as time passed during the course of COVID-19. Three patients (2.86%) were tested positive for 2019-nCoV nucleic acid again in nasal and throat swabs after discharge.Conclusions:The positive rate of 2019-nCoV nucleic acid was higher in the early stage of disease. 2019-nCoV nucleic acid can be detected in incubation period, and virus shedding may last for a long period.
