Analysis of an outbreak of clustered diarrhea caused by co-infection with norovirus GII.13 and GII.17
10.3760/cma.j.cn112866-20210813-00147
- VernacularTitle:一起由诺如病毒GII.13和GII.17混合感染引起聚集性腹泻疫情的分析
- Author:
Zhenlu SUN
1
;
Xiaoming XING
;
Peihua NIU
;
Ruiqing ZHANG
;
Qiao GAO
;
Ji WANG
;
Xuejun MA
Author Information
1. 中国疾病预防控制中心病毒病预防控制研究所 国家卫生健康委员会医学病毒和病毒病重点实验室，北京 102206
- Keywords:
Norovirus;
Diarrhea;
Outbreak;
Epidemics
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(6):639-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To clarify the pathogen types, genotypes and molecular biological characteristics of an outbreak in a high school in Yantai city in 2019, and to provide evidence for epidemic prevention and control.Methods:Eleven samples were collected from a high school in Yantai city in 2019. Quantitative PCR was used for primary type identification. RT-PCR and specific primers were used to amplify the target genes, and the sequences of norovirus were compared and analyzed for phylogenetic analysis.Results:The pathogen of this cluster outbreak was norovirus. Five GII-positive samples of norovirus were detected, 4 of which were GII.13 and 1 was GII.17. Sequence analysis of polymerase-capsid region showed that the amino acid sequence of this cluster outbreak was highly conserved.Conclusions:This outbreak is a cluster of diarrhea caused by GII.13 and GII.17 norovirus infection. The analysis of this outbreak is helpful to our general understanding of the evolution, genetic diversity and distribution of norovirus, and the surveillance of norovirus in the jurisdiction should be further strengthened.
