Distribution characteristics and related factors of hepatitis B surface antibody levels in infants born to chronic HBV infected women
10.3760/cma.j.cn112866-20210829-00153
- VernacularTitle:慢性HBV感染女性所生婴儿乙肝表面抗体水平分布特征及相关因素的研究
- Author:
Fangfang SUN
1
;
Xiaoyue BI
;
Xiaojuan WANG
;
Zhan ZENG
;
Yanjie LIN
;
Liu YANG
;
Wen DENG
;
Tingting JIANG
;
Yuanjiao GAO
;
Leiping HU
;
Mengjiao XU
;
Lu ZHANG
;
Yao LU
;
Minghui LI
;
Yao XIE
Author Information
1. 首都医科大学附属北京地坛医院肝病二科，北京 100015
- Keywords:
Hepatitis B virus;
Anti-hepatitis B surface antibody;
Mother-to-child transmission;
Hepatitis B vaccine;
Logistic regression analysis
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(6):631-638
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution characteristics and related factors of HBsAb in infants born to women with chronic hepatitis B virus (HBV) infection.Methods:A total of 605 infants born to women with chronic HBV infection who met the requirements for inclusion were selected as the subjects. Information about the mother′s previous HBV infection, biochemical indicators during pregnancy, pregnancy complications, information about delivery, and hepatitis B test result after birth were collected. HBsAg and HBsAb at the age of 1 year were determined, and HBsAg and HBsAb at the age of 7 months were retrospectively collected. The factors influencing HBsAb in infants were analyzed by ordered logistic regression.Results:In 605 infants, the infection rate was about 1%. Among them, 6 infants were positive for HBsAg and HBV DNA at 7 months and 1 year of age. Uninfected infants were divided into groups according to HBsAb titers. The result showed that there were significant differences in prothrombin activity (PTA) ( χ2=11.17, P=0.01), positive rate of HBeAg ( χ2=7.87, P=0.049) and HBsAg positive rate at birth ( χ2=10.52, P=0.02) among different groups. Multivariate ordered Logistic regression analysis showed that HBsAg negative at birth was an independent protective factor for HBsAb at 7 months of age ( OR=1.564, 95% CI 1.092-2.239, P=0.015). Logistic regression analysis of HBsAb at 1 year of age showed maternal gestational diabetes mellitus ( OR=1.578, 95% CI 1.126-2.210, P=0.008), infant enhanced immunization ( OR=81.207, 95% CI 31.202-211.352, P < 0.001) and antibody level at 7 months of age ( OR=42.123, 95% CI 22.824-77.739, P < 0.001) were independently associated with HBsAb at 1 year of age. Conclusions:HBsAg negative in venous blood at birth was an independent protective factor for HBsAb at 7 months of age, and enhanced immunization was an independent protective factor for HBsAb at 1 year of age.
