Pathogen spectrum of viral encephalitis and meningitis in children in Shijiazhuang city and surrounding areas in 2018
10.3760/cma.j.cn112866-20200927-00257
- VernacularTitle:2018年石家庄市及周边地区儿童病毒性脑炎及脑膜炎病原学研究
- Author:
Tao FAN
1
;
Chuanze HU
;
Yanjie HAN
;
Huili QUAN
;
Yishuo SUN
;
Jing MA
;
Panhui YU
;
Zhengde XIE
;
Wei WANG
;
Meng ZHANG
;
Yanxia QIAO
;
Suzhen SUN
;
Xiangpeng CHEN
Author Information
1. 石家庄市第四医院 河北医科大学附属妇产医院 050000
- Keywords:
Viral encephalitis and meningitis;
Pathogen;
Enterovirus
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(5):566-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the pathogenic characteristics of viral encephalitis or meningitis in children living in Shijiazhuang city and surrounding areas, and to study the relationship between pathogenic and clinical findings.Methods:A total of 132 cerebrospinal fluid specimens were randomly collected from hospitalized children diagnosed with viral encephalitis or meningitis (January 2018 to December 2018) in the Department of Neurology of Hebei Children′s Hospital in Shijiazhuang city and surrounding areas. The nucleic acids of four viruses in cerebrospinal fluid were detected by real-time quantitative PCR. SPSS 21.0 software was used for statistical analysis.Results:Among the 132 cases, 78 were boys and 54 were girls, with a sex ratio of 1.44∶1. However, in the gender composition of children in each age group, there was no significant difference (χ 2=3.901, P=0.272). Of the 132 children, 121 had signs of fever, 109 had symptoms of headache, 92 had symptoms of vomiting, 17 had abnormal electroencephalogram(EEG), and 15 had abnormal head magnetic resonance imaging(MRI). 132 cerebrospinal fluid specimens were tested for pathogenic pathogens, and 80 of them were successfully detected. There was 1 case of human herpesvirus type I(HHV-I), 2 cases of varicella-zoster virus (VZV) and 77 cases of enterovirus(EV). The age group of 1~3 years′s EV detection rate was 66.67%, it is the highest, but overall, the EV detection rate, there was no significant difference among the four age groups (χ 2=3.147, P=0.369). The detection rate of EV in summer and autumn were 65.52% and 70.83%, respectively, which were significantly higher than those in spring and winter (33.33% and 0.00%), and there was a significant difference (χ 2=22.504, P=0.000). There was no significant difference in the positive rates of fever, headache and vomiting between EV-positive and non-EV-positive children ( P>0.05). There was no significant difference in the incidence of abnormal EEG and abnormal head MRI between EV-positive and non-EV-positive children ( P>0.05). Conclusions:In 2018, EV was the main pathogen of viral encephalitis and meningitis in children in Shijiazhuang city and surrounding areas, and EV detection rate was high in summer and autumn.
