Investigation of neutralizing antibodies of polioviruses among the children<12 years old during 2018 and 2019, Fujian
10.3760/cma.j.cn112866-20210317-00049
- VernacularTitle:2018—2019年福建省12岁以下儿童脊髓灰质炎病毒中和抗体水平调查
- Author:
Xiuhui YANG
1
;
Yong ZHOU
;
Shuangli ZHU
;
Ningxuan ZHENG
;
Zhifei CHEN
;
Dongyan WANG
;
Dongmei YAN
;
Xiaolei LI
;
Hairong ZHANG
;
Suhan ZHANG
;
Dong LI
Author Information
1. 福建省疾病预防控制中心 福建省人兽共患病重点实验室，福州 350001
- Keywords:
Poliomyelitis;
Oral poliovirus attenuated live vaccine;
Neutralizing antibody;
Immune level
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(5):548-554
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of vaccine switch on the levels of neutralizing antibody (NA) of poliovirus in children aged<12 years.Methods:Subjects aged<12 years from 9 districts in Fujian province were chosen by stratified cluster and complete random sampling method. Blood samples were collected for testing NA of poliovirus by microcell neutralization.Results:A total of 2 134 subjects aged<12 years were selected. The positive rate of NA against PVⅠand Ⅲ were 98.64% and 95.83%; and geometric mean titers (GMTs) were 1∶259.35 and 1∶105.14, respectively. The GMTs presented a trend of decreasing as age increased. Compared to trivalent oral poliovirus vaccine (tOPV), bivalent oral poliovirus vaccine (bOPV) and inactivated poliovirus vaccine (IPV) induced higher GMTs of NA against poliovirusⅠand Ⅲ respectively. Among 182 children aged<5 years, the positive rate of NA against PVⅠ, Ⅱ, Ⅲ were 97.25%, 76.37% and 92.86%. There were statistical differences among the three types ( χ2=44.44, P=0.000). The rate of NA against PVⅡwas significantly lower than those ofⅠand Ⅲ (Ⅱ vs. I: χ2=34.65, P=0.000; Ⅱ vs. Ⅲ: χ2=18.99, P=0.000). And the GMTs of NA against PV Ⅰ, Ⅱ, Ⅲ were 1∶368.96、1∶23.06 and 1∶183.10, which were significantly different ( F=156.54, P=0.000). The GMT of PVⅠwas the highest, PV Ⅲ was the second, PVⅡ was lowest (pairwise comparison showed values of P all were 0.000). The analysis of general linear model showed that the interval between the date of last immunization and the date of sample collection would affect the GMTs of PVⅠand Ⅲ, different vaccine models would affect only the GMT of PV Ⅰ. The age maybe was a confounding factor. But no factors would affect the GMT of PV Ⅱ. Conclusions:After the vaccine switch, the level of NA against PVⅠand PV Ⅲ were still maintaining high level, but the level of PVⅡamong children<5 years was at relatively low level, which indicated that the surveillance should be strengthened.
