Sub-genotype 2B-L2c rubella virus was found in Qinghai province in 2020
10.3760/cma.j.cn112866-20210508-00076
- VernacularTitle:2020年青海省发现风疹病毒2B-L2c基因亚型
- Author:
Lixia FAN
1
;
Chonghai LI
;
Xiaotong WANG
;
Qianlan LI
;
Chunxiang WANG
;
Shengcang ZHAO
;
Zhen ZHU
Author Information
1. 青海省疾病预防控制中心，西宁 810007
- Keywords:
Rubella;
Rubella virus;
Sub-genotype 2B-L2c
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(5):536-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the epidemiological characteristics of rubella and the genetic characteristics of rubella virus (RV) circulated in Qinghai province in 2020, so as to provide scientific basis for optimization and improvement of local rubella prevention and control strategy.Methods:The rubella epidemiological characteristics were analyzed by summarizing the data on the rubella incidence in Qinghai province in 2020 from the National Notifiable Disease Reporting System. Through Qinghai provincial measles and rubella laboratory network, throat swab samples from susceptible rubella outbreak and sporadic cases in 2020 were collected and identified. RV strains were obtained after three passages of virus isolation from positive samples. After extracting the viral RNA, the 739 nucleotide fragments within the E1 gene were amplified and determined to identify the genotype and sub-genotype of the Qinghai strains in 2020 and further analyzed the molecular differences between Qinghai strains and the RV strains circulated in China.Results:In 2020, the rubella incidence in Qinghai province had shown an obvious upward trend, and the age of onset had shifted to adolescents in the 10-19 years of age group (accounting for 94.9%). Totally 29 RV strains were isolated from four high incidence areas of rubella in Qinghai province. All RV strains were identified as sub-genotype 2B-L2c, which is also the dominant subtype of RV circulated in China. In addition, virological surveillance data showed that there were different transmission chains of sub-genotype 2B-L2c in Qinghai province in 2020, and an outbreak might be caused by different transmission chain viruses.Conclusions:The accumulation of rubella susceptible population aged 10-19 years and the transmission of new imported 2B-L2c virus had led to the rubella reemergence and outbreaks in several cities in Qinghai province in 2020.
