Detection of small marker chromosome in patients with Turner's syndrome by flourescence in situ hybridization
10.3321/j.issn:1673-4254.2001.04.016
- VernacularTitle:荧光原位杂交法检测特纳氏综合征患者的微小标记染色体
- Author:
Lan-Lin SONG
1
;
Xiao-Li LIU
;
Song QUAN
;
Mei ZHONG
Author Information
1. First Military Medical University
- From:
Journal of Southern Medical University
2001;21(4):292-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the origin of small marker chromosome (smr) in the patients with Turner's syndrome. Method The small marker chromosome in 3 patients with Turner's syndrome, whose karyotype was 45, X / 46, X+smr, was hybridized by centromere DNA probe of X and Y chromosome through fluorescence in situ hybridization(FISH). Results The small marker chromosome in 2 patients were derived from Y chromosome and in the other patient, it was from X chromosome. Conclusion FISH can be applied to detect small marker chromosome, which is important to clinical diagnosis and the choice of therapy.
