Effect of increased bite force on the expression of IL-1β in rat alveolar bone osteoblasts
10.3321/j.issn:1673-4254.2001.04.011
- VernacularTitle:咀嚼压力增强对大鼠牙槽骨白细胞介素-1β表达的影响
- Author:
Lin YUAN
1
;
Wei-Dong ZHOU
;
Yun-Feng ZHAO
Author Information
1. Zhujiang Hospital, First Military Medical University
- From:
Journal of Southern Medical University
2001;21(4):276-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the molecular mechanism of alveolar bone remodeling by studying the dynamic changes of IL- 1β expression in rat alveolar bone osteoblasts. Methods Rat models of increased bite force of the back teeth were established, and the expression of IL-1β in the alveolar bone osteoblasts were determined by HE staining and immunohistochemistry. Observation of the changes in the histological morphology of the periodontium was conducted microscopically. Rats with normal bite force served as control. Results The increase of bite force (within the physiological limit) induced the widening of the periodontal ligament and the osteogenesis in the alveolar bone. Significant enhancement of IL-1β expression was observed in the osteoblasts of rats with increased bite force, in comparison with that in the rats with normal bite force. Conclusion Increased bite force causes higher expression levels of IL-1β in the alveolar bone osteoblasts, initiating the destruction process of the bone but simultaneously the activation of the ossification, suggesting that IL-1β plays an important role in the regulation of periodontium remodeling in response to changes in the bite force
