Role of immunogenetic factors in chronic hepatitis B
10.3760/cma.j.cn112866-20200911-00241
- VernacularTitle:免疫遗传因素在慢性HBV感染中的作用
- Author:
Yanjie LIN
1
;
Jingjing WANG
;
Huihui LU
;
Minghui LI
;
Yao XIE
Author Information
1. 北京大学地坛医院教学医院肝病二科，北京 100015
- Keywords:
Chronic hepatitis B;
Immune genetic determinants;
Single nucleotide polymorphism;
Innate toll-like receptor;
Human leukocyte antigen
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(4):476-480
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) can not cause hepatocellular disease directly after infecting the host. Instead, it causes cytopathic disease through the interaction with the host immune system, thereby advances the disease. Age, sex, ethnicity, etc. of HBV infected persons are associated with different clinical outcomes after HBV infects the host. However, different outcomes can even occur when the hosts have the same race, sex, and age are infected with the same HBV subtype in the same way. It suggests that the host immune genetic factors play a decisive role. The single nucleotide polymorphism (SNP) of innate immunity, adaptive immunity and related genetic factors in cytokine pathways is closely related to different clinical prognosis. This article mainly reviews the latest research progress in immune genetic factors association with chronic HBV infection, and summarizes the potential role and clinical significance of the host immune genetic determinants of chronic HBV infection, hoping to provide help for clinical practice.
