Pathological and clinical analysis of patients with chronic hepatitis B virus infection with normal or slightly abnormal liver transaminases
10.3760/cma.j.cn112866-20200810-00224
- VernacularTitle:肝功能正常或轻度异常慢性HBV感染者的临床及病理分析
- Author:
Hongjie LI
1
;
Xuesong GAO
;
Nan LIU
;
Yijin ZHANG
;
Lili GAO
;
Ping GAO
;
Xuefei DUAN
Author Information
1. 首都医科大学附属北京地坛医院综合科，北京 100015
- Keywords:
Hepatitis B virus;
Alanine transaminase;
Pathology
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(4):448-452
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the indications for the treatment of chronic hepatitis B (CHB) by analyzing the clinical and pathological features of patients with normal or slightly abnormal liver function.Methods:Retrospective analysis of the clinical and pathological features of 259 patients of chronic hepatitis B virus (HBV) infection with normal or mildly abnormal liver transaminases was made in the study. Relationships of pathological changes in liver tissues and gender, age, hepatitis B e antigen (HBeAg) status, alanine aminotransferase (ALT) level, aspartate aminotransferase (AST) level, HBV DNA load, FIB-4 index, liver elasticity were analyzed.Results:In 259 patients of chronic hepatitis B virus infection with normal or slightly abnormal liver transaminases, 79 cases (30.50%) had score of inflammation necrosis≥G2, 67 cases (25.87%) had score of fibrosis≥S2, and 99 cases (38.22%) had inflammation necrosis≥G2 or fibrosis≥S2. There were no significant differences in liver inflammation grades and fibrosis stages among different gender, age, HBeAg status, or ALT level( P>0.05). There were significant differences in liver inflammation grades between AST≤19 U/L group and AST>19 U/L group( χ2=8.43, P<0.01). There were significant differences in fibrosis19 U/L has important clinical value in judging whether antiviral treatment is needed.
