Pathogen distribution of herpangina in Shanghai city, 2017-2019
10.3760/cma.j.cn112866-20201016-00266
- VernacularTitle:2017—2019年上海市疱疹性咽峡炎病原学分析
- Author:
Jiajing LIU
1
;
Jiayu WANG
;
Yanqiu ZHOU
;
Xi ZHANG
;
Zheng TENG
Author Information
1. 上海市疾病预防控制中心 200336
- Keywords:
Herpangina;
Enterovirus;
Serotypes
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(4):437-440
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the etiologic characteristics of herpangina (HA) in Shanghai city, so as to provide scientific basis for HA control and prevention.Methods:Throat swabs of HA cases during 2017-2019 from sentinel hospital were collected. Fluorescent quantitative RT-PCR was conducted to detect nucleic acid of enterovirus (EV), EV-A71, coxsackievirus (CV)-A16, CV-A6 and CV-A10. Virus isolation was performed for the other EV-positive samples. The isolates were genotyped using semi-nested RT-PCR(RT-snPCR). The data were statistically analyzed with Excel and IBM SPSS Statistics 22.0.Results:A total of 264 HA cases were included, of whom 32.95%(87/264) were under 1 year of age, the human enteroviruses (HEVs)-positive rate was 69.70%(184/264), eight serotypes of EV including EV-A71, CV-A16, CV-A6, CV-Al0, CV-A4, CV-A2, CV-A5 and CV-B5 were detected. The CV-A6-positive rate was the highest with a percentage of 39.13%(72/184), followed by CV-A10 (17.39%, 32/184) and CV-A4 (16.85%, 31/184). From 2017 to 2019, the proportion of other EV increased year by year, which were 19.23% (10/52), 41.10% (30/73) and 47.46% (28/59), respectively.Conclusions:CV-A6, CV-A10 and CV-A4 were the main common pathogens of HA in Shanghai city during 2017-2019, and the proportion of other EV increased year by year.
