Dynamic changes and influencing factors of neutralizing antibody in COVID-19 cases
10.3760/cma.j.cn112866-20210104-00001
- VernacularTitle:新型冠状病毒肺炎病例血清中和抗体动态变化及影响因素
- Author:
Xingle LI
1
;
Shidong LU
;
Jinyue LI
;
Weirong SONG
;
Bicong WU
;
Hongxia MA
;
Jiayong ZHAO
;
Haixia WANG
;
Ying YE
;
Xueyong HUANG
;
Wanshen GUO
Author Information
1. 河南省疾病预防控制中心传染病预防控制所 河南省传染病病原生物重点实验室，郑州 450016
- Keywords:
Coronavirus Disease 2019 (COVID-19);
2019 novel Coronavirus (2019-nCoV);
Neutralizing antibody;
Protective rate
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(3):341-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the dynamic changes and possible influencing factors of anti-2019 novel Coronavirus (2019-nCoV) neutralizing antibody in confirmed Coronavirus Disease 2019 (COVID-19) cases.Methods:Microneutralization was used to test the anti-2019-nCoV neutralizing antibody. Excel 2007 and SPSS 22.0 were used for data processing and analysis.Results:There were 420 serum samples collected from 155 confirmed COVID-19 cases. These serum samples contained acute phase serum, convalescent phase serum and serum from cases recovered for about six months. The sampling time was 0-221 days after the onset of COVID-19. The geometric mean titer (GMT) of anti-2019-nCoV neutralizing antibody was 1∶13 at 1 week, and 1∶31 at 2 week. The titers of anti-2019-nCoV neutralizing antibody of individual cases were still<1∶4 on the 15 th day. The GMT was all over 1: 52 (13×4) at 6-32 week. Taking 1: 64 as the cut-off point, the serum anti-2019-nCoV neutralizing antibody positive rates was 30.56% in acute phase serum samples (0-14 d, 0-2 w), 82.31% in convalescent phase serum samples (36-63 d, 6-9 w) and 86.52% in serum samples from cases recovered for about six months (183-210 d, 27-30 w). Statistical analysis showed that there was no significant difference in anti-2019-nCoV neutralizing antibody levels at the other weeks except 1-2 week ( χ2=9.270, P=0.931), there was no statistically differences in gender, age and occupation of the cases, and also between the normal and mild cases ( P>0.05). Conclusions:The serum anti-2019-nCoV neutralizing antibody level is only statistically correlated with the disease progression of COVID-19, and maintain the protective level from 3 to 30 week.
