Observation of the therapeutic effect of oXiris blood purification to alleviate cytokine storm in severe COVID-19 patients
10.3760/cma.j.cn112866-20201102-00276
- VernacularTitle:应用oXiris血液净化减轻COVID-19重症患者细胞因子风暴的治疗效果观察
- Author:
Ying XIA
1
;
Hui MA
;
Xiangfeng LI
;
Siyao WANG
;
Baokun XING
;
Hui YANG
;
Yanwei ZHAO
Author Information
1. 中国医学科学院北京协和医院 100730
- Keywords:
COVID-19;
oXiris;
Cytokine storm;
Blood purification
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(3):335-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the therapeutic effect of blood purification with oXiris on cytokine storm in severe COVID-19 patients.Methods:In February to April, 2020 in the intensive care unit (ICU) of a hospital in Wuhan, 7 cases with severe COVID-19 as the study participant, treated with oXiris for blood purification. The general information of patients, the basic information of the blood purification treatment, blood purification treatment before and after treatment for 24 hours, 48 hours, 72 hours of routine blood, liver and kidney function and inflammatory markers were collected to understand the trend of change.Results:The number of blood purification treatment of 7 patients were 2.13±1.64 times, and the duration of blood purification was 66.31±48.73 hours. Treatment was interrupted twice due to hypothermia. After treatment, the level of interleukin 6 (IL-6) of the patients decreased from (1342.20±1822.01) pg/ml before treatment to (202.69±276.24) pg/ml in 4 cases decreased by more than 90% and in 2 cases decreased by 63% and 77%. The level of TNF decreased from 51.94±59.64 pg/ml before treatment to 18.93±9.84 pg/ml, and TNF decreased by 28%~78% in 4 patients. The hypersensitive C-reactive protein (HS-CRP) of the patients decreased from 147.81±100.54 mg/L before treatment to 89.43±108.31 mg/L after treatment, in 4 cases decreased by 63% to 91%.Conclusions:oXiris blood purification treatment can effectively reduce inflammatory markers in patients with severe COVID-19. Correct use of oXiris filter during treatment can prolong the life of the filter. During the treatment, the pressure monitoring value and whether there is thrombosis in the pipeline should be closely observed and recorded. Meanwhile, it is necessary to keep patients warm to prevent hypothermia in. The application of ultrasound to monitor blood coagulation and venous thrombosis plays a positive role in preventing the occurrence of pulmonary embolism.
