Enterovirus D68 and A71 infections and their related central nervous system disease

VernacularTitle:肠道病毒D68型和A71型感染及相关中枢神经系统性疾病
Author: Lingxuan SU ¹ ; Lei FANG ; Wenwu YAO ; Hao YAN ; Yi SUN ; Yanjun ZHANG
Author Information

1. 浙江中医药大学医学技术与信息工程学院检验系，杭州　310053
Keywords: Enterovirus; Viral encephalitis; Aseptic meningitis; Acute flaccid paralysis
From: Chinese Journal of Experimental and Clinical Virology 2021;35(3):328-334
CountryChina
Language:Chinese
Abstract: The genus Enterovirus (EV) of the family Picornaviridae containing more than 100 serotypes. These viruses cause a variety of diseases, among which viral encephalitis (VE), aseptic meningitis (AM) and acute flaccid paralysis (AFP) much threaten human health. Infections with these viruses will cause severe neurological complications and death. EV is a frequent cause of infection in children, especially in neonates and young infants. EV infections form a seasonal pattern and the incidence is the highest in the summer and autumn. In this review, we discuss our current understanding of EV structure, host-receptor interactions, epidemiological characteristics, related central nervous system diseases and laboratory diagnostics. Moreover, we briefly explain the mechanism of viral genome replication and assembly for most relevant pathogens and describe diseases prevention and control method. We reflect on how these recent discoveries may help the development of strategies to decrease viral spread.