Research progress in chronic hepatitis B and functional cure based on immune mechanism
10.3760/cma.j.cn112866-20201026-00271
- VernacularTitle:基于免疫机制的慢性乙型肝炎与功能性治愈研究进展
- Author:
Xiaoyue BI
1
;
Cheng CHENG
;
Huihui LU
;
Minghui LI
;
Yao XIE
Author Information
1. 首都医科大学附属北京地坛医院肝病二科 100015
- Keywords:
Hepatitis B virus;
Immunization;
HBsAg;
Functional cure
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(3):317-321
- CountryChina
- Language:Chinese
-
Abstract:
The functional cure of hepatitis B means that patients have good clinical outcomes, which is the ideal endpoint of hepatitis B antiviral treatment. Whether chronic hepatitis B patients can achieve functional cure is related to the nature of the virus itself, such as virus species, virus replication and expression of related proteins, on the other hand, it is also related to the host body's immunity, including innate immunity and specific immunity. Immune factors play a vital role in the functional cure of hepatitis B. Antiviral drugs, including interferon, often play an antiviral role by regulating immunity. This paper reviews the relationship between hepatitis B and functional cure from the perspective of immunity, in order to provide the basis for the clinical pursuit of functional cure, hoping to provide guidance for clinical practice.
