The influence of nucleos(t)ide analogs on the accuracy of HBV DNA and RNA quantitative detection
10.3760/cma.j.cn112866-20201114-00287
- VernacularTitle:核苷(酸)类药物对慢性乙型肝炎患者血清HBV DNA和RNA定量检测的影响
- Author:
Mingchen LIU
1
;
Xingwen YANG
;
Siwen PENG
;
Jun ZOU
;
Fengmin LU
Author Information
1. 北京大学基础医学院 病原生物学系暨感染病中心 100191
- Keywords:
Chronic hepatitis B;
Nucleos(t)ide analogs;
Nucleic acid quantification
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(3):305-311
- CountryChina
- Language:Chinese
-
Abstract:
Nucleos(t)ide analogs (NAs) are one of the two main antiviral agents used in clinical practice, which can effectively inhibit HBV replication. Serum HBV DNA is one of the most commonly used virologic markers used to assess HBV replication level. In recent years, more and more studies have suggested that serum HBV RNA is one of the ideal surrogates of cccDNA activity. This article summarized the influence of serum viral nucleic acid properties and quantitative result during treatment with NAs, as well as current method of viral nucleic acid quantification. And finally, it evaluates the significance of HBV DNA and RNA joint testing for CHB treatment.
