Analysis of the epidemiologic characteristics and detection of the pathogens in children with hand, foot and mouth disease during 2016-2019
10.3760/cma.j.cn112866-20200720-00210
- VernacularTitle:2016—2019年手足口病病原体流行病学特征分析
- Author:
Haiyun HU
1
;
Mingyi CAI
;
Wei GE
Author Information
1. 上海市儿童医院 上海交通大学附属儿童医院 200040
- Keywords:
Hand, foot and mouth disease;
Enterovirus;
Epidemiologic characteristic
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(3):291-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the current epidemic situation of etiological agents, analyze the characteristics’ differences in children with hand, foot and mouth disease and to provide relevant data for observing, treating, and preventing hand, foot and mouth disease.Methods:Epidemiological analysis on the cases diagnosed of hand, foot and mouth disease from January 2016 to December 2019 in our clinic service. Collected specimens included stool and throat swabs to detect the pathogens. The specimens were tested by RT-PCR assay with enterovirus consensus primer and specific primer for enterovirus 71(EV71) and coxsackievirus A16(CV-A16)and so on, respectively.Results:Totally 522 specimens were collected, the overall positive rate was 90.4%; CV-A6 infection was mainly popular in four years. The epidemic characteristics of enterovirus infection within 2016-2019 had significant differences ( P=0.00); the second one was CoxA16, the third one was Ev71, the fourth one was CV-A10, these four types of enterovirus within 2016-2019 had significant differences ( P<0.001; P<0.001; p=0.03); the ratio of sex and age-group had significant difference in CV-A6 group ( P=0.007); the endemic distribution had significant difference ( P<0.05); EV71 and CV-A16 approximately emerged from spring to summer ( P<0.001); CV-A6 was at the most prevalent position, the prevelant seasons were autumn and winter ( P<0.001). Conclusions:HFMD showed alternant epidemic characteristics at different times of enterovirus infection. Analyzing the differences of epidemiologic characteristics of enterovirus infection is helpful to prevent and control enterovirus infection, and also is useful for early identification of severe cases and handling the outbreaks.
