Mechanism of RNA m6A methylation involved in the replication of hepatitis B and C viruses and development of hepatocellular carcinoma

VernacularTitle:RNA m6A修饰参与乙型和丙型肝炎病毒复制及相关肝癌发生机制研究进展
Author: Kunyan QIAO ¹ ; Rui SU ; Bei JIANG ; Fengmei WANG
Author Information

1. 天津市第二人民医院　天津市肝病医学研究所　300192
Keywords: RNA; m6A; Hepatitis virus; Hepatocellular carcinoma
From: Chinese Journal of Experimental and Clinical Virology 2021;35(2):237-241
CountryChina
Language:Chinese
Abstract: RNA methylation is one of the hot topics in the study of epigenetics recently and N6-methyladenosine (m6A) modification is the main type of methylation in mammals RNA. The latest studies have found that RNA m6A methylation plays a significant role in the replication of hepatitis B and C viruses and development of related liver cancer. This paper aims to review the research progress on the roles and mechanisms of RNA m6A in the replication of hepatitis viruses and development of hepatocellular carcinoma (HCC), which might provide the theoretical basis and new research insights for the related diseases.