Preventive and therapeutic effect of acidic fibroblast growth factor on traumatic brain edema in rats

VernacularTitle:酸性成纤维细胞生长因子对大鼠创伤性脑水肿的防治作用
Author: Qing-Hua WANG ¹ ; Ru-Xiang XU ; Ying-Qian CAI ; Yu-Xi ZOU
Author Information

1. Zhujiang Hospital, First Military Medical University
Keywords: brain trauma; aFGF; treatment
From: Journal of Southern Medical University 2000;20(6):491-492
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of acidic fibroblastic growth factor (aFGF) on traumatic brain edema. Methods Recombinant human aFGF (10mg/ml) was continuously injected into the intraventricle for 12 h before brain traumatic injury in rats, and the brain water content was determined and the histological and ultrastructural changes in the brain tissue observed. Results Brain edema and neuronal damage were reduced remarkably by the administration of aFGF. Conclusion aFGF can obviously alleviate brain edema and neuronal damage.