Analysis on characteristics of untreated 16-25 years old people living with HIV-1 at the China-Myanmar border from 2009 to 2017 based on molecular network method
10.3760/cma.j.cn112866-20201023-00270
- VernacularTitle:基于分子网络方法分析2009—2017年中缅边境未治疗16～25岁HIV-1感染者流行特征
- Author:
Yibo DING
1
;
Min CHEN
;
Jibao WANG
;
Yi FENG
;
Mengze GAN
;
Lijie WANG
;
Qianru LIN
;
Lin HE
;
Yanling MA
;
Mengjie HAN
;
Liying MA
Author Information
1. 中国疾病预防控制中心性病艾滋病预防控制中心 传染病预防控制国家重点实验室，北京 102206
- Keywords:
HIV-1;
Molecular network;
Assortativity;
China-Myanmar border
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(2):124-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the epidemiological characteristics of untreated 16-25 years old people living with HIV-1 (PLWH) in Dehong on the China-Myanmar border during 2009 to 2017, by using molecular network method and to provide references for precise prevention and reduction of the spread of HIV-1 in Dehong.Methods:Screening people living with HIV-1, collecting blood sample and separating plasma, extracting RNA were performed to amplify HIV-1 pol sequence, construct molecular network by HIV-TRACE program and conduct statistical analysis. Results:Among the 573 infected persons in the group, 319 were Chinese (55.67%), 254 were Burmese (44.33%); 351 were males (61%), and 222 were females (39%); 404 had heterosexual transmission (HET, 70.51%), 110 people injected drugs (PWID, 19.20%), 51 men had sex with men (MSM, 8.9%); genotypes included 252 unique recombinant forms (43.98%), and 222 had circular recombinant forms (39.02%), 76 had HIV-1 C (13.26%) and 23 HIV-1 B (4.01%) infection. The 83 molecular networks constructed through HIV-TRACE involved 250 PLWH, 49% were the China-Myanmar mixed network (41/83). Myanmar citizens were at high risk of accessing the China-Myanmar mixed network ( AOR=2.676, p=0.002). Chinese male PWID network assortativity is 0.34, Myanmar male PWID was 0.14, MSM was 0.12. Conclusions:There is a continuous risk of cross-border transmission of HIV-1 in Dehong on the China-Myanmar border; attention should be paid to the mixed transmission of MSM and Myanmar male PWID populations with other transmission routes.
