Functional role of T follicular regulatory cell in antibody response to virus infection and immunization
10.3760/cma.j.cn112866-20200924-00254
- VernacularTitle:滤泡调节性T细胞在病毒感染与疫苗免疫中的作用及机制研究进展
- Author:
Ziyan LIU
1
;
Jian ZHANG
;
Yabin HU
;
Wenpei LIU
Author Information
1. 南华大学附属郴州医院，郴州 423000
- Keywords:
Virus;
T Follicular regulatory cell;
T Follicular helper cell;
Neutralizing antibody;
Vaccine
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(1):116-120
- CountryChina
- Language:Chinese
-
Abstract:
T follicular regulatory cell (Tfr) is a unique subset of CD4 + T cells discovered in recent years. They are derived from T regulatory cell (Treg) and presenting simultaneously similar biological characteristics of Treg cell and T follicular helper cell (Tfh). Tfr cell are mainly manifested as participating in the regulation of Tfh cell and B cell differentiation in the lymph node germinal center (GC), assisting in the screening of high-affinity antibodies and preventing the production of autoantibodies, ensuring immune homeostasis. This article describes the research progress in the biological characteristics and functions of Tfr cell, and summarized the role of Tfr cell in the antibody response after virus infection and vaccine immunization. The aim is to deeply understand the immune regulation mechanism of antibody production and maturation after virus infection, to provide insight for virus vaccine design and immune strategy evaluation.
