EFFECT OF COXSACKIEVIRUS B3 ON ION CHANNEL CURRENTS IN RAT VENTRICULAR MYOCYTES
- Author:
Weisheng BAO
1
;
Gongxin LIU
;
Chunlei WANG
;
Yingzhen YANG
;
Qi GUO
;
Yong YU
Author Information
1. Shanghai Institute of Cardiovascular Diseases ZhongShan Hospital of Shanghai Medical University
- Keywords:
coxsackievirus B3;
cardiomyocytes;
ion channel current
- From:
Chinese Medical Sciences Journal
2000;15(3):150-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective. To investigate the effects of coxsackievims B3 (CVB3) on ion channel currents in rat ventricular my-Methods. Rat hearts were isolated with collagenase to acquire single ventricular myocytes, L-type voltnge-depen-dent calcium channel( VDCC)current (Ica), Na + current (INa), outward potassium current (Iout), inwardly rectifying potassium current(IKI) were recorded using whole cell patch clamp techniques. Results. CVB3 infection increased Ica and Iout, while decreased IKI; but it had no obvious effect on INa. Conclusion. Tne effects of CVB3 on Ica、 Iout、 IKI may be one of the mechanisms of myocytes damage and the oc-currence of abnormal electroactivities induced by CVB3 infection.
