STUDY OF THE RELATIONSHIP BETWEEN PSORIASIS AND THE POLYMORPHIC SITE C677T OF METHYLENETETRAHYDROFOLATE REDUCTASE
- Author:
Baiqiu WANG
1
;
Songbin FU
;
Guiyin ZHANG
;
Pu LI
Author Information
1. Harbin Medical University
- Keywords:
MTHFR;
PCR-RFLP;
psoriasis;
gene mutation
- From:
Chinese Medical Sciences Journal
2000;15(2):119-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective. In order to investigate 5,10-methylenetetrahydrofolate reductase (MTHFR)s polymorphic changes in psoriasis vulgaris.Methods.We detected mutation of site C677V of MTHFR in 39 psoriastics by PCR-RFLP.Results.Genotype frequencies of the psoriastics were C/C＝20.15%,C/T＝48.72% and T/T＝30.77%; the allelic frequencies were C＝0.4487 and T＝0.5513. Homozygous mutant (TT) of the psoriastics was significantly different from the normal control group by X2 test.Conclusion.C677V mutant of MTHFR might be related with psoriasis.
