Clinical significance of galectin-3 and HPV16/18-E6 expression in laryngeal carcinoma patients
10.3760/cma.j.cn112866-20200927-00256
- VernacularTitle:喉癌组织中Galectin-3和HPV16/18-E6蛋白的表达及临床意义
- Author:
Wei WEI
1
;
Yuezhang WU
;
Kang XIAO
;
Yuntao SONG
;
Guohui XU
;
Qi SHI
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所 头颈外科恶性肿瘤发病机制及转化研究教育部重点实验室 100142
- Keywords:
Galectin-3;
Laryngeal carcinoma;
Immunohistochemistry;
Western blot;
Lymph node metastasis
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(6):621-624
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression and clinical significance of galectin-3 and HPV16/18-E6 proteins in laryngeal carcinoma patients.Methods:Immunohistochemistry and Western blot method were used to observe the expressions of galectin-3 protein and HPV16/18-E6 protein in laryngeal carcinoma tissues of 60 patients. SAS 9.4 software was used to analyze the relationship between the galectin-3 protein and the clinical stage severity, pathological grades and lymph node metastasis in all the cases. Results:The result of immunohistochemical examinations showed that the positive rate of galectin-3 protein expression was 78.3% (47/60), and the Western blot result showed that the galectin-3 protein expression in tumor tissues was significantly higher than that in adjacent normal tissues. Statistical analysis showed that galectin-3 expression was correlated with the severity of clinical staging, differentiation of the tumor and lymph node metastasis of laryngeal cancer. There was no correlation between the expression of galectin-3 protein and the 16/18-E6 protein of human papillomavirus.Conclusions:The expression of galectin-3 protein showed a gradually increasing trend with the aggravation of the clinical severity of laryngeal carcinoma, providing certain experimental data for the early diagnosis and treatment of laryngeal cancer.
