Relationship between matrix metalloproteinase-8, myeloperoxidase and human cytomegalovirus infection and atherosclerotic plaque type in ischemic cerebrovascular disease patients
10.3760/cma.j.cn112866-20200814-00225
- VernacularTitle:ICVD患者MMP-8、MPO及HCMV感染与AS斑块类型关系研究
- Author:
Wenluo ZHANG
1
;
Lu YANG
;
Nana LIU
;
Chaosheng PENG
Author Information
1. 北大医疗康复医院，北京 102206
- Keywords:
Ischemic cerebrovascular disease;
Carotid atherosclerosis;
plaque type;
MMP-8;
MPO;
Human cytomegalovirus
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(6):636-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between serum matrix metalloproteinase-8 (MMP-8), myeloperoxidase (MPO), human cytomegalovirus (HCMV) infection and the type of carotid atherosclerosis in patients with ischemic cerebrovascular disease (ICVD).Methods:From February 2017 to May 2019, 90 patients with ischemic cerebrovascular disease diagnosed by Peking University Medical Rehabilitation Hospital were selected as study group and 90 healthy adult persons who underwent health checkup as control group, and the study group was divided into non-stable plaque type group (30 cases) and stable plaque type group (30 cases) according to the ultrasonic imaging data and referring to the type of carotid plaque of the patients. The patients whose plaque property were between the two groups were were enrolled as the middle type group (30 cases). The relationship between human cytomegalovirus PP65 antigen (HCMV-PP65) in the serum, MMP-8, MPO and peripheral blood white blood cells and carotid atherosclerotic plaque in patients with ischemic cerebrovascular disease was analyzed.Results:The serum MMP-8, MPO level and HCMV-PP65 positive rate in the 3 study groups were significantly higher than that of the control group ( P<0.05), and the serum MMP-8 in different plaque types groups was significantly higher in the study group and the control group than in the control group. The higher the level of MPO and the positive rate of HCMV-PP65, the higher the serum MMP-8 and MPO level in the middle plaque type group, and the positive rate of HCMV-PP65 in the middle plaque type group was higher than that of the stable plaque group and the unstable plaque group ( P<0.05). Conclusions:The serum MMP-8, the MPO level and the HCMV infection are related to the unstable type of the carotid atherosclerosis plaque in the patients with the ischemic cerebrovascular disease, and the recognition of the carotid atherosclerosis is improved; it is an important link to control the severity of patients with ischemic cerebrovascular disease and to take timely and effective prevention and treatment measures.
